The Il23a Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to IL23A, and interleukin 23 subunit alpha. This antibody recognizes Human, and Rat antigen. The Il23a Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated has been validated for the following applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis